Ontology highlight
ABSTRACT:
SUBMITTER: Dai W
PROVIDER: S-EPMC5665863 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Nature communications 20171101 1
Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool. Here we use quantitative analysis of Wnt, Hh, and Notch signalling reporters and the cell fate markers Eyes Absent (Eya) and Castor (Cas) to study the effects of hyper-activation and loss of niche signals on progenitor development in the Drosophila ovary. Follicle stem cell (FSC) ...[more]