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Platelets and Multi-Organ Failure in Sepsis.


ABSTRACT: Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.

SUBMITTER: Greco E 

PROVIDER: S-EPMC5666881 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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Platelets and Multi-Organ Failure in Sepsis.

Greco Elisabetta E   Lupia Enrico E   Bosco Ornella O   Vizio Barbara B   Montrucchio Giuseppe G  

International journal of molecular sciences 20171020 10


Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroa  ...[more]

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