Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.
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ABSTRACT:
SUBMITTER: Jakel C
PROVIDER: S-EPMC5673892 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.
Jäkel Cornelia C Bergmann Frank F Toth Reka R Assenov Yassen Y van der Duin Daniel D Strobel Oliver O Hank Thomas T Klöppel Günter G Dorrell Craig C Grompe Markus M Moss Joshua J Dor Yuval Y Schirmacher Peter P Plass Christoph C Popanda Odilia O Schmezer Peter P
Nature communications 20171106 1
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppr ...[more]
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