Ontology highlight
ABSTRACT:
SUBMITTER: Pitaval A
PROVIDER: S-EPMC5674878 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Pitaval Amandine A Senger Fabrice F Letort Gaëlle G Gidrol Xavier X Guyon Laurent L Sillibourne James J Théry Manuel M
The Journal of cell biology 20171009 11
Primary cilia are sensory organelles located at the cell surface. Their assembly is primed by centrosome migration to the apical surface, yet surprisingly little is known about this initiating step. To gain insight into the mechanisms driving centrosome migration, we exploited the reproducibility of cell architecture on adhesive micropatterns to investigate the cytoskeletal remodeling supporting it. Microtubule network densification and bundling, with the transient formation of an array of cold- ...[more]