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Breaking barriers to novel analgesic drug development.

ABSTRACT: Acute and chronic pain complaints, although common, are generally poorly served by existing therapies. This unmet clinical need reflects a failure to develop novel classes of analgesics with superior efficacy, diminished adverse effects and a lower abuse liability than those currently available. Reasons for this include the heterogeneity of clinical pain conditions, the complexity and diversity of underlying pathophysiological mechanisms, and the unreliability of some preclinical pain models. However, recent advances in our understanding of the neurobiology of pain are beginning to offer opportunities for developing novel therapeutic strategies and revisiting existing targets, including modulating ion channels, enzymes and G-protein-coupled receptors.

SUBMITTER: Yekkirala AS

PROVIDER: S-EPMC5675565 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

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Breaking barriers to novel analgesic drug development.

Yekkirala Ajay S AS Roberson David P DP Bean Bruce P BP Woolf Clifford J CJ

Nature reviews. Drug discovery 20170609 8

Acute and chronic pain complaints, although common, are generally poorly served by existing therapies. This unmet clinical need reflects a failure to develop novel classes of analgesics with superior efficacy, diminished adverse effects and a lower abuse liability than those currently available. Reasons for this include the heterogeneity of clinical pain conditions, the complexity and diversity of underlying pathophysiological mechanisms, and the unreliability of some preclinical pain models. Ho ...[more]

PMID: 28596533

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Dataset Information

Breaking barriers to novel analgesic drug development.

Publications

Breaking barriers to novel analgesic drug development.

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