Ontology highlight
ABSTRACT:
SUBMITTER: Han N
PROVIDER: S-EPMC5675693 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Han Na N Hu Guangyuan G Shi Lei L Long Guoxian G Yang Lin L Xi Qingsong Q Guo Qiuyun Q Wang Jianhua J Dong Zhen Z Zhang Mengxian M
Oncotarget 20170930 50
Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients. Furthermore, using the CRISPR/Cas9 system, we investigated the effects of <i>Notch1</i> downregulation on clonogenic growth and angiogenesis of GBM cells and xenografts. Immunohistochemistry showed positive Notch1 expression in 71% (49/69) of ...[more]