Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Brown BM
PROVIDER: S-EPMC5675772 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.
Brown Belinda M BM Sohrabi Hamid R HR Taddei Kevin K Gardener Samantha L SL Rainey-Smith Stephanie R SR Peiffer Jeremiah J JJ Xiong Chengjie C Fagan Anne M AM Benzinger Tammie T Buckles Virginia V Erickson Kirk I KI Clarnette Roger R Shah Tejal T Masters Colin L CL Weiner Michael M Cairns Nigel N Rossor Martin M Graff-Radford Neill R NR Salloway Stephen S Vöglein Jonathan J Laske Christoph C Noble James J Schofield Peter R PR Bateman Randall J RJ Morris John C JC Martins Ralph N RN
Alzheimer's & dementia : the journal of the Alzheimer's Association 20170511 11
<h4>Introduction</h4>The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.<h4>Methods</h4>In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ<sub>42,</sub> and CSF tau levels was evaluated using linear regression. ...[more]
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