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Data on atherosclerosis specific antibody conjugation to nanoemulsions.

ABSTRACT: This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide). Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.

SUBMITTER: Prevot G

PROVIDER: S-EPMC5676083 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Data on atherosclerosis specific antibody conjugation to nanoemulsions.

Prévot Geoffrey G Duonor-Cérutti Martine M Larivière Mélusine M Laroche-Traineau Jeanny J Jacobin-Valat Marie Josée MJ Barthélémy Philippe P Clofent-Sanchez Gisèle G Crauste-Manciet Sylvie S

Data in brief 20171026

This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional lin ...[more]

PMID: 29159220

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