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Comparative rates of upstaging and upgrading in Caucasian and Korean prostate cancer patients eligible for active surveillance.


ABSTRACT: To investigate the impact of race on the risk of pathological upgrading and upstaging at radical prostatectomy (RP) in an Asian (Korean) and Western (Caucasian) cohort eligible for active surveillance (AS).We performed a retrospective cohort study of 854 patients eligible for AS who underwent RP in United States (n = 261) and Korea (n = 593) between 2006 and 2015. After adjusting for age, PSA level, and prostate volume, we utilized multivariate logistic regression analysis to assess the effect of race on upgrading or upstaging.There were significant differences between Caucasian and Korean patients in terms of age at surgery (60.2 yr. vs. 64.1 yr.), PSA density (0.115 ng/mL/mL vs. 0.165 ng/mL/mL) and mean number of positive cores (3.5 vs. 2.4), but not in preoperative PSA values (5.11 ng/mL vs. 5.05 ng/mL). The rate of upstaging from cT1 or cT2 to pT3 or higher was not significantly different between the two cohorts (8.8% vs. 11.0%, P = 0.341). However, there were higher rates of upgrading to high-grade cancer (Gleason 4+3 or higher) in Korean patients (9.1%) when compared to Caucasian counterparts (2.7%) (P = 0.003). Multivariate logistic regression analysis showed that age (OR 1.07, P < 0.001) and smaller prostate volume (OR 0.97, P < 0.001), but not race, were significantly associated with upstaging or upgrading.There were no differences in rates of upgrading or upstaging between Caucasian and Korean men eligible for active surveillance.

SUBMITTER: Jeon HG 

PROVIDER: S-EPMC5685613 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Comparative rates of upstaging and upgrading in Caucasian and Korean prostate cancer patients eligible for active surveillance.

Jeon Hwang Gyun HG   Yoo Jae Ho JH   Jeong Byong Chang BC   Seo Seong Il SI   Jeon Seong Soo SS   Choi Han-Yong HY   Lee Hyun Moo HM   Ferrari Michelle M   Brooks James D JD   Chung Benjamin I BI  

PloS one 20171114 11


<h4>Purpose</h4>To investigate the impact of race on the risk of pathological upgrading and upstaging at radical prostatectomy (RP) in an Asian (Korean) and Western (Caucasian) cohort eligible for active surveillance (AS).<h4>Materials and methods</h4>We performed a retrospective cohort study of 854 patients eligible for AS who underwent RP in United States (n = 261) and Korea (n = 593) between 2006 and 2015. After adjusting for age, PSA level, and prostate volume, we utilized multivariate logis  ...[more]

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