KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression.
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ABSTRACT:
SUBMITTER: Ma D
PROVIDER: S-EPMC5691198 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression.
Ma Dong D Chang Ling-Ya LY Zhao Shan S Zhao Jun-Jian JJ Xiong Yan-Jie YJ Cao Fu-Yuan FY Yuan Lu L Zhang Qi Q Wang Xin-Yue XY Geng Mei-Li ML Zheng Huan-Yu HY Li Ou O
Scientific reports 20171116 1
Although the transcription factor Krüppel-like factor 5 (KLF5) plays important roles in both inflammation and cancer, the mechanism by which this factor promotes cervical carcinogenesis remains unclear. In this study, we demonstrated a potential role for tumour necrosis factor receptor superfamily member 11a (TNFRSF11a), the corresponding gene of which is a direct binding target of KLF5, in tumour cell proliferation and invasiveness. Coexpression of KLF5 and TNFRSF11a correlated significantly wi ...[more]
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