Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.
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ABSTRACT:
SUBMITTER: Perez-Mockus G
PROVIDER: S-EPMC5693868 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.
Perez-Mockus Gantas G Mazouni Khalil K Roca Vanessa V Corradi Giulia G Conte Vito V Schweisguth François F
Nature communications 20171117 1
Embryo-scale morphogenesis arises from patterned mechanical forces. During Drosophila gastrulation, actomyosin contractility drives apical constriction in ventral cells, leading to furrow formation and mesoderm invagination. It remains unclear whether and how mechanical properties of the ectoderm influence this process. Here, we show that Neuralized (Neur), an E3 ubiquitin ligase active in the mesoderm, regulates collective apical constriction and furrow formation. Conversely, the Bearded (Brd) ...[more]
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