Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC5702905 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Chen Chunli C Wicha Sebastian G SG de Knegt Gerjo J GJ Ortega Fatima F Alameda Laura L Sousa Veronica V de Steenwinkel Jurriaan E M JEM Simonsson Ulrika S H USH
CPT: pharmacometrics & systems pharmacology 20171010 11
The aim of this study was to investigate pharmacodynamic (PD) interactions in mice infected with Mycobacterium tuberculosis using population pharmacokinetics (PKs), the Multistate Tuberculosis Pharmacometric (MTP) model, and the General Pharmacodynamic Interaction (GPDI) model. Rifampicin, isoniazid, ethambutol, or pyrazinamide were administered in monotherapy for 4 weeks. Rifampicin and isoniazid showed effects in monotherapy, whereas the animals became moribund after 7 days with ethambutol or ...[more]