Ontology highlight
ABSTRACT:
SUBMITTER: D'Hondt V
PROVIDER: S-EPMC5707051 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
D'Hondt Véronique V Lacroix-Triki Magalie M Jarlier Marta M Boissiere-Michot Florence F Puech Carole C Coopman Peter P Katsaros Dionyssios D Freiss Gilles G
Oncotarget 20170921 56
<h4>Background</h4>Chromosome 4q loss of heterozygosity (LOH) is frequently observed in high-grade serous ovarian carcinoma (HGSOC). However, this LOH has not been clearly associated with the inactivation of any tumor suppressor gene(s). As the tumor suppressor gene <i>PTPN13</i> is located on chromosome 4q21, we investigated its expression in HGSOC.<h4>Methods</h4>PTPN13 protein expression was investigated by immunohistochemistry (IHC) in normal ovary epithelium and in 30 HGSOC samples, whereas ...[more]