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Organocatalytic asymmetric chlorinative dearomatization of naphthols.

ABSTRACT: An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.

SUBMITTER: Yin Q

PROVIDER: S-EPMC5707459 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

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Organocatalytic asymmetric chlorinative dearomatization of naphthols.

Yin Qin Q Wang Shou-Guo SG Liang Xiao-Wei XW Gao De-Wei DW Zheng Jun J You Shu-Li SL

Chemical science 20150427 7

An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation. ...[more]

PMID: 29218183

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