Ontology highlight
ABSTRACT:
SUBMITTER: Chengye W
PROVIDER: S-EPMC5732803 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Chengye Wang W Yu Tian T Ping Shao S Deguang Sun S Keyun Wang W Yan Wang W Rixin Zhang Z Rui Liang L Zhenming Gao G Mingliang Ye Y Liming Wang W
Oncotarget 20171031 61
Metformin had exerted important inhibitory effects in multiple cancers. However, the correlation between metformin and hepatocellular carcinoma (HCC) metastasis, and the relevant mechanisms are still unclear. By quantitative proteomics analysis technique, we found metformin could suppress FGF signalling significantly. In FGF signalling basic fibroblast growth factor (bFGF) is a crucial member, it initially binds to its receptors, the complex of bFGF and receptors activate FGF signallings, and pr ...[more]