Ontology highlight
ABSTRACT:
SUBMITTER: Di Matteo S
PROVIDER: S-EPMC7844056 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Di Matteo Sabina S Nevi Lorenzo L Overi Diletta D Landolina Nadine N Faccioli Jessica J Giulitti Federico F Napoletano Chiara C Oddi Andrea A Marziani Augusto M AM Costantini Daniele D De Rose Agostino M AM Melandro Fabio F Bragazzi Maria C MC Grazi Gian Luca GL Berloco Pasquale B PB Giuliante Felice F Donato Giuseppe G Moretta Lorenzo L Carpino Guido G Cardinale Vincenzo V Gaudio Eugenio E Alvaro Domenico D
Scientific reports 20210128 1
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment of iCCA is enriched of Cancer-Stem-Cells expressing Epithelial-to-Mesenchymal Transition (EMT) traits, being these features associated with aggressiveness and drug resistance. Treatment with the anti-diabetic drug Metformin, has been recently associated with reduced incidence of iCCA. We aimed to evaluate the anti-cancerogenic effects of ...[more]