Dataset Information

A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD.

ABSTRACT: OBJECTIVES:Although many secondary effects of high levels of vanadium (V) and chromium (Cr) overlap with symptoms seen in paediatric patients with chronic kidney disease (CKD), their plasma V and Cr levels are understudied. DESIGN:Ancillary cross-sectional study to a prospective, longitudinal, randomised controlled trial. SETTING:Children's Hospital of Western Ontario, London Health Sciences Centre, London, Ontario, Canada. PARTICIPANTS:36 children and adolescents 4-18 years of age with CKD. INTERVENTIONS:1-6 trace element measurements per patient. Cystatin C (CysC) estimated glomerular filtration rate (eGFR) was calculated using the Filler formula. Plasma V and Cr levels were measured using high-resolution sector field inductively coupled mass spectrometry. Anthropomorphic data and blood parameters were collected from our electronic chart programme. Water Cr and V data were obtained from the Ontario Water (Stream) Quality Monitoring Network. PRIMARY AND SECONDARY OUTCOME MEASURES:Primary outcomes: plasma Cr and V. SECONDARY OUTCOMES:age, season, CysC, CysC eGFR, and Cr and V levels in environmental water. RESULTS:The median (IQR) eGFR was 51?mL/min/1.73?m2 (35, 75). The median V level was 0.12?µg/L (0.09, 0.18), which was significantly greater than the 97.5th percentile of the reference interval of 0.088?µg/L; 32 patients had at least one set of V levels above the published reference interval. The median Cr level was 0.43?µg/L (0.36, 0.54), which was also significantly greater than the established reference interval; 34 had at least one set of Cr levels above the published reference interval. V and Cr levels were moderately correlated. Only some patients had high environmental exposure. CONCLUSIONS:Our study suggests that paediatric patients with CKD have elevated plasma levels of V and Cr. This may be the result of both environmental exposure and a low eGFR. It may be necessary to monitor V and Cr levels in patients with an eGFR <30?mL/min/1.73?m2. TRIAL REGISTRATION NUMBER:NCT02126293; HC#172241.

SUBMITTER: Filler G

PROVIDER: S-EPMC5734203 | biostudies-other | 2017 Jun

REPOSITORIES: biostudies-other

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A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD.

Filler Guido G Kobrzynski Marta M Sidhu Hargun Kaur HK Belostotsky Vladimir V Huang Shih-Han S SS McIntyre Chris C Yang Liju L

BMJ open 20170606 5

<h4>Objectives</h4>Although many secondary effects of high levels of vanadium (V) and chromium (Cr) overlap with symptoms seen in paediatric patients with chronic kidney disease (CKD), their plasma V and Cr levels are understudied.<h4>Design</h4>Ancillary cross-sectional study to a prospective, longitudinal, randomised controlled trial.<h4>Setting</h4>Children's Hospital of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.<h4>Participants</h4>36 children and adolescents 4- ...[more]

PMID: 28592575

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Dataset Information

A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD.

Publications

A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD.

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