Ontology highlight
ABSTRACT:
SUBMITTER: Zarone MR
PROVIDER: S-EPMC5738363 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Zarone Mayra Rachele MR Misso Gabriella G Grimaldi Anna A Zappavigna Silvia S Russo Margherita M Amler Evzen E Di Martino Maria Teresa MT Amodio Nicola N Tagliaferri Pierosandro P Tassone Pierfrancesco P Caraglia Michele M
Scientific reports 20171220 1
MiR-34a acts as tumor suppressor microRNA (miRNA) in several cancers, including multiple myeloma (MM), by controlling the expression of target proteins involved in cell cycle, differentiation and apoptosis. Here, we have investigated the combination between miR-34a and γ-secretase inhibitor (γSI), Sirtinol or zoledronic acid (ZOL) in order to enhance the inhibitory action of this miRNA on its canonical targets such as Notch1 and SIRT1, and on Ras/MAPK-dependent pathways. Our data demonstrate tha ...[more]