COPs and POPs Patrol Inflammasome Activation.
Ontology highlight
ABSTRACT:
SUBMITTER: Indramohan M
PROVIDER: S-EPMC5766406 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Publications
COPs and POPs Patrol Inflammasome Activation.
Indramohan Mohanalaxmi M Stehlik Christian C Dorfleutner Andrea A
Journal of molecular biology 20171010 2
Sensing and responding to pathogens and tissue damage is a core mechanism of innate immune host defense, and inflammasomes represent a central cytosolic pattern recognition receptor pathway leading to the generation of the pro-inflammatory cytokines interleukin-1β and interleukin-18 and pyroptotic cell death that causes the subsequent release of danger signals to propagate and perpetuate inflammatory responses. While inflammasome activation is essential for host defense, deregulated inflammasome ...[more]
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