Ontology highlight
ABSTRACT:
SUBMITTER: Goulet DR
PROVIDER: S-EPMC5767869 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Goulet Dennis R DR Orcutt Steven J SJ Zwolak Adam A Rispens Theo T Labrijn Aran F AF de Jong Rob N RN Atkins William M WM Chiu Mark L ML
The Journal of biological chemistry 20171117 2
Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrate therapeutic promise based on novel mechanisms of action. Among the many platforms for creating bsAbs, controlled Fab-arm exchange (cFAE) has proven useful based on minimal changes to native Ab structure and the simplicity with which bsAbs can be formed from two parental Abs. Despite a published protocol for cFAE and its widespread use in the pharmaceutical industry, the reaction mechanism has not ...[more]