Ontology highlight
ABSTRACT:
SUBMITTER: Hosoi A
PROVIDER: S-EPMC5773695 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Hosoi Akihiro A Takeda Kazuyoshi K Nagaoka Koji K Iino Tamaki T Matsushita Hirokazu H Ueha Satoshi S Aoki Shin S Matsushima Kouji K Kubo Masato M Morikawa Teppei T Kitaura Kazutaka K Suzuki Ryuji R Kakimi Kazuhiro K
Scientific reports 20180118 1
To facilitate the optimization of cancer immunotherapy lacking immune-related adverse events, we performed TCR repertoire analysis of tumor-infiltrating CD8<sup>+</sup> T-cells in B16 melanoma-bearing mice receiving anti-PD-1, anti-CTLA-4, anti-4-1BB, anti-CD4 or a combination of anti-PD-1 and 4-1BB antibodies. Although CD8<sup>+</sup> T-cells in the tumor were activated and expanded to a greater or lesser extent by these therapies, tumor growth suppression was achieved only by anti-PD-1, anti-P ...[more]