Ontology highlight
ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC5776818 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
He Xing X Sun Yue Y Lei Nanhang N Fan Xiaobin X Zhang Cheng C Wang Yange Y Zheng Kuiyang K Zhang Dongmei D Pan Weiqing W
Proceedings of the National Academy of Sciences of the United States of America 20171218 1
Aberrant expression of microRNAs (miRNAs) underlies a spectrum of human diseases including organ fibrosis, and hepatic stellate cells (HSCs) are the main effectors of hepatic fibrosis. Here, we showed that the expression of host <i>miR-351</i> in HSCs was markedly reduced during the early stage of <i>Schistosoma</i> infection. However, this expression was significantly increased during the later stage of infection (after 52 d of infection). The elevated levels of <i>miR-351</i> promoted hepatic ...[more]