Ontology highlight
ABSTRACT:
SUBMITTER: Dhar M
PROVIDER: S-EPMC5803213 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Dhar Manjima M Wong Jessica J Che James J Matsumoto Melissa M Grogan Tristan T Elashoff David D Garon Edward B EB Goldman Jonathan W JW Sollier Christen Elodie E Di Carlo Dino D Kulkarni Rajan P RP
Scientific reports 20180207 1
Metastatic non-small cell lung cancer (NSCLC) is a highly fatal and immunogenic malignancy. Although the immune system is known to recognize these tumor cells, one mechanism by which NSCLC can evade the immune system is via overexpression of programmed cell death ligand 1 (PD-L1). Recent clinical trials of PD-1 and PD-L1 inhibitors have returned promising clinical responses. Important for personalizing therapy, patients with higher intensity staining for PD-L1 on tumor biopsies responded better. ...[more]