Ontology highlight
ABSTRACT:
SUBMITTER: Zhao P
PROVIDER: S-EPMC5808582 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Zhao Peng P Wong Kai In KI Sun Xiaoli X Reilly Shannon M SM Uhm Maeran M Liao Zhongji Z Skorobogatko Yuliya Y Saltiel Alan R AR
Cell 20180201 4
The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy stora ...[more]