Ontology highlight
ABSTRACT:
SUBMITTER: Razvag Y
PROVIDER: S-EPMC5821895 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Razvag Yair Y Neve-Oz Yair Y Sajman Julia J Reches Meital M Sherman Eilon E
Nature communications 20180221 1
T cells have a central function in mounting immune responses. However, mechanisms of their early activation by cognate antigens remain incompletely understood. Here we use live-cell multi-colour single-molecule localization microscopy to study the dynamic separation between TCRs and CD45 glycoprotein phosphatases in early cell contacts under TCR-activating and non-activating conditions. Using atomic force microscopy, we identify these cell contacts with engaged microvilli and characterize their ...[more]