Ontology highlight
ABSTRACT:
SUBMITTER: Casas J
PROVIDER: S-EPMC4248239 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature communications 20141127
The earliest molecular events in T-cell recognition have not yet been fully described, and the initial T-cell receptor (TCR)-triggering mechanism remains a subject of controversy. Here, using total internal reflection/Forster resonance energy transfer microscopy, we observe a two-stage interaction between TCR, CD8 and major histocompatibility complex (MHC)-peptide. There is an early (within seconds) interaction between CD3ζ and the coreceptor CD8 that is independent of the binding of CD8 to MHC, ...[more]