Ontology highlight
ABSTRACT:
SUBMITTER: Alshekaili J
PROVIDER: S-EPMC5824848 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Alshekaili Jalila J Chand Rochna R Lee Cindy Eunhee CE Corley Susan S Kwong Kristy K Papa Ilenia I Fulcher David A DA Randall Katrina L KL Leiding Jennifer W JW Ma Cindy S CS Wilkins Marc R MR Uzel Gulbu G Goodnow Chris C CC Vinuesa Carola G CG Tangye Stuart G SG Cook Matthew C MC
Scientific reports 20180223 1
A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1<sup>hi</sup>, but compared to their CD57- PD-1<sup>hi</sup> counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly, circulating PD-1+ CD57+ CD4+ T cells make less cytokine than ...[more]