Ontology highlight
ABSTRACT:
SUBMITTER: Ullrich E
PROVIDER: S-EPMC5824870 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Ullrich Evelyn E Abendroth Benjamin B Rothamer Johanna J Huber Carina C Büttner-Herold Maike M Buchele Vera V Vogler Tina T Longerich Thomas T Zundler Sebastian S Völkl Simon S Beilhack Andreas A Rose-John Stefan S Wirtz Stefan S Weber Georg F GF Ghimire Sakhila S Kreutz Marina M Holler Ernst E Mackensen Andreas A Neurath Markus F MF Hildner Kai K
The Journal of clinical investigation 20180129 3
Acute graft-versus-host disease (GVHD) represents a severe, T cell-driven inflammatory complication following allogeneic hematopoietic cell transplantation (allo-HCT). GVHD often affects the intestine and is associated with a poor prognosis. Although frequently detectable, proinflammatory mechanisms exerted by intestinal tissue-infiltrating Th cell subsets remain to be fully elucidated. Here, we show that the Th17-defining transcription factor basic leucine zipper transcription factor ATF-like ( ...[more]