Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC5831850 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Sun Wei W Liu Caixia C Chen Qiuhui Q Liu Ning N Yan Youyou Y Liu Bin B
Oxidative medicine and cellular longevity 20180213
Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD<sup>+</sup>-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation. SIRT3 regulates gl ...[more]