Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC5835818 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Zhang Jinjin J Ren Juchao J Hao Shengjie S Ma Fang F Xin Yan Y Jia Wenxiao W Sun Yundong Y Liu Zhifang Z Yu Han H Jia Jihui J Li Wenjuan W
American journal of translational research 20180215 2
Our previous work discovered that the histone demethylase JMJD2B (KDM4B) plays oncogenic roles in gastric carcinogenesis, but the regulatory mechanism of JMJD2B in gastric cancer has not been well defined. It has been revealed that microRNAs function as gene regulators by binding to the 3'UTR of mRNAs to inhibit gene expression. In this study, we found that miR-491-5p suppressed cell proliferation, invasion and migration by directly targeting the JMJD2B 3'UTR in gastric cancer. Moreover, miR-491 ...[more]