Ontology highlight
ABSTRACT:
SUBMITTER: Wallenius K
PROVIDER: S-EPMC5841867 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Wallenius Kristina K Thalén Pia P Björkman Jan-Arne JA Johannesson Petra P Wiseman John J Böttcher Gerhard G Fjellström Ola O Oakes Nicholas D ND
JCI insight 20171005 19
GPR81 is a receptor for the metabolic intermediate lactate with an established role in regulating adipocyte lipolysis. Potentially novel GPR81 agonists were identified that suppressed fasting plasma free fatty acid levels in rodents and in addition improved insulin sensitivity in mouse models of insulin resistance and diabetes. Unexpectedly, the agonists simultaneously induced hypertension in rodents, including wild-type, but not GPR81-deficient mice. Detailed cardiovascular studies in anestheti ...[more]