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Optical property uncertainty estimates for spatial frequency domain imaging.


ABSTRACT: Spatial frequency domain imaging (SFDI) is a wide-field diffuse optical imaging modality that has attracted considerable interest in recent years. Typically, diffuse reflectance measurements of spatially modulated light are used to quantify the optical absorption and reduced scattering coefficients of tissue, and with these, chromophore concentrations are extracted. However, uncertainties in estimated absorption and reduced scattering coefficients are rarely reported, and we know of no method capable of providing these when look-up table (LUT) algorithms are used to recover the optical properties. We present a method to generate optical property uncertainty estimates from knowledge of diffuse reflectance measurement errors. By employing the Cramér-Rao bound, we can quickly and efficiently explore theoretical SFDI performance as a function of spatial frequencies and sample optical properties, allowing us to optimize spatial frequency selection for a given application. In practice, we can also obtain useful uncertainty estimates for optical properties recovered with a two-frequency LUT algorithm, as we demonstrate with tissue-simulating phantom and in vivo experiments. Finally, we illustrate how absorption coefficient uncertainties can be propagated forward to yield uncertainties for chromophore concentrations, which could significantly impact the interpretation of experimental results.

SUBMITTER: Pera V 

PROVIDER: S-EPMC5854069 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Optical property uncertainty estimates for spatial frequency domain imaging.

Pera Vivian V   Karrobi Kavon K   Tabassum Syeda S   Teng Fei F   Roblyer Darren D  

Biomedical optics express 20180118 2


Spatial frequency domain imaging (SFDI) is a wide-field diffuse optical imaging modality that has attracted considerable interest in recent years. Typically, diffuse reflectance measurements of spatially modulated light are used to quantify the optical absorption and reduced scattering coefficients of tissue, and with these, chromophore concentrations are extracted. However, uncertainties in estimated absorption and reduced scattering coefficients are rarely reported, and we know of no method ca  ...[more]

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