Ontology highlight
ABSTRACT:
SUBMITTER: Yang CT
PROVIDER: S-EPMC5856799 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Yang Cheng-Ta CT Li Jhy-Ming JM Chu Wing-Keung WK Chow Shu-Er SE
Cell death & disease 20180401 4
The overexpression of lumican has been found in lung cancer cells; however, the functional role of lumican in lung cancer cells remains unclear. In this study, we found lumican functioned as a tubulin-binding protein and the depletion of lumican by transfection with its specific shRNA increased lung cancer cell invasion. Such alterations led to morphological changes and actin cytoskeleton remodeling, including the induction of membrane ruffling or protrusion and stress fiber formation, correlate ...[more]