Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5856828 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Wang Xiaoyuan X Yin Hang H Zhang Hongxia H Hu Jing J Lu Hailing H Li Chunhong C Cao Mengru M Yan Shi S Cai Li L
Cell death & disease 20180401 4
Acquired resistance to epidermal growth factor receptor-tyrosine-kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, is a critical obstacle in the treatment of EGFR mutant-positive non-small cell lung cancer (NSCLC). EHD1, a protein of the C-terminal Eps15 homology domain-containing (EHD) family, plays a role in regulating endocytic recycling, but the mechanistic details involved in EGFR-TKI resistance and cancer stemness remain largely unclear. Here, we found that a lower EHD1 expre ...[more]