Ontology highlight
ABSTRACT:
SUBMITTER: Ito Y
PROVIDER: S-EPMC5860932 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Ito Yoko Y Schaefer Niccolette N Sanchez Amelia A Francisco David D Alam Rafeul R Martin Richard J RJ Ledford Julie G JG Stevenson Connor C Jiang Di D Li Liwu L Kraft Monica M Chu Hong Wei HW
Journal of innate immunity 20180127 2
Toll-interacting protein (Tollip) is a key negative regulator of innate immunity by preventing excessive proinflammatory responses. Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. Whether Tollip regulates lung inflammation in a type 2 cytokine milieu (e.g., IL-13) is unclear. Our goal was to determine the in vivo role of Tollip in IL-13-mediated lung eosinophilic inflammation and the underlying mechanisms. Tollip-knockout (KO) and wi ...[more]