Ontology highlight
ABSTRACT:
SUBMITTER: Zamarin D
PROVIDER: S-EPMC5873884 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Zamarin Dmitriy D Ricca Jacob M JM Sadekova Svetlana S Oseledchyk Anton A Yu Ying Y Blumenschein Wendy M WM Wong Jerelyn J Gigoux Mathieu M Merghoub Taha T Wolchok Jedd D JD
The Journal of clinical investigation 20180305 4
Intralesional therapy with oncolytic viruses (OVs) leads to the activation of local and systemic immune pathways, which may present targets for further combinatorial therapies. Here, we used human tumor histocultures as well as syngeneic tumor models treated with Newcastle disease virus (NDV) to identify a range of immune targets upregulated with OV treatment. Despite tumor infiltration of effector T lymphocytes in response to NDV, there was ongoing inhibition through programmed death ligand 1 ( ...[more]