Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy.
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ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7228744 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy.
Li Zhaoting Z Wang Yixin Y Shen Yuexin Y Qian Chenggen C Oupicky David D Sun Minjie M
Science advances 20200515 20
Anti-programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select patients with cancer. However, insufficient lymphocytic infiltration, weak T cell-induced inflammation, and immunosuppressive cell accumulation in the tumor microenvironment (TME) may greatly diminish the efficacy. Here, we report development of the FX@HP nanocomplex composed of fluorinated polymerized CXCR4 antagonism (FX) and paclitaxel-loaded human serum albumin (HP) for pulmonary delivery of anti-PD- ...[more]
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