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Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.

ABSTRACT: Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress immune responses. Thus, the research and development of novel anticancer peptides with low toxicity to normal human cells and mechanisms of action capable of avoiding multi-drug resistance may provide a new method for anticancer treatment. This review provides useful information on the potential of marine anticancer peptides for human therapy.

SUBMITTER: Kang HK

PROVIDER: S-EPMC5877780 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.

Kang Hee Kyoung HK Choi Moon-Chang MC Seo Chang Ho CH Park Yoonkyung Y

International journal of molecular sciences 20180320 3

Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress ...[more]

PMID: 29558431

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