Ontology highlight
ABSTRACT:
SUBMITTER: Carpier JM
PROVIDER: S-EPMC5881459 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
The Journal of experimental medicine 20180212 4
The adapter molecule linker for activation of T cells (LAT) orchestrates the formation of signalosomes upon T cell receptor (TCR) stimulation. LAT is present in different intracellular pools and is dynamically recruited to the immune synapse upon stimulation. However, the intracellular traffic of LAT and its function in T lymphocyte activation are ill defined. We show herein that LAT, once internalized, transits through the Golgi-trans-Golgi network (TGN), where it is repolarized to the immune s ...[more]