Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC5906566 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Nature communications 20180418 1
Vaccines to induce effective and sustained antitumor immunity have great potential for postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-specific immunity and abolishing immune resistance continues to be a challenge. Here we present a personalized cancer vaccine (PVAX) for postsurgical immunotherapy. PVAX is developed by encapsulating JQ1 (a BRD4 inhibitor) and indocyanine green (ICG) co-loaded tumor cells with a hydrogel matrix. Activation of PVAX by ...[more]