Dataset Information

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies.

ABSTRACT: Two synergistic approaches to the facile assembly of complex ?-trifluoromethyl alkenes are described. Using ?-trifluoromethyl-?-silyl alcohols as masked trifluoromethyl alkenes, cross-coupling or related functionalization processes at distal electrophilic sites can be executed without inducing Peterson elimination. Subsequent Lewis acidic activation affords functionalized ?-trifluoromethyl alkenes. Likewise, the development of a novel ?-trifluoromethylvinyl trifluoroborate reagent complements this approach and allows a one-step cross-coupling of (hetero)aryl halides to access a broad array of complex ?-trifluoromethyl alkenes.

SUBMITTER: Phelan JP

PROVIDER: S-EPMC5916225 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies.

Phelan James P JP Wiles Rebecca J RJ Lang Simon B SB Kelly Christopher B CB Molander Gary A GA

Chemical science 20180222 12

Two synergistic approaches to the facile assembly of complex α-trifluoromethyl alkenes are described. Using α-trifluoromethyl-β-silyl alcohols as masked trifluoromethyl alkenes, cross-coupling or related functionalization processes at distal electrophilic sites can be executed without inducing Peterson elimination. Subsequent Lewis acidic activation affords functionalized α-trifluoromethyl alkenes. Likewise, the development of a novel α-trifluoromethylvinyl trifluoroborate reagent complements th ...[more]

PMID: 29732105

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Project description:A series of tetrathiafulvalenes functionalized with one or two trifluoromethyl electron-withdrawing groups (EWG) is obtained by phosphite coupling involving CF3-substituted 1,3-dithiole-2-one derivatives. The relative effects of the EWG such as CF3, CO2Me and CN on the TTF core were investigated from a combination of structural, electrochemical, spectrochemical and theoretical investigations. Electrochemical data confirm the good correlations between the first oxidation potential of the TTF derivatives and the ?meta Hammet parameter, thus in the order CO2Me < CF3 < CN, indicating that, in any case, the mesomeric effect of the substituents is limited. Besides, crystal structure determinations show that the deformation of the unsymmetrically substituted dithiole rings, when bearing one, or two different EWG, and attributed to the mesomeric effect of ester or nitrile groups, is not notably modified or counter-balanced by the introduction of a neighboring trifluoromethyl group. DFT calculations confirm these observations and also show that the low energy HOMO-LUMO absorption band found in nitrile or ester-substituted TTFs is not found in TTF-CF3, where, as in TTF itself, the low energy absorption band is essentially attributable to a HOMO?LUMO + 1 transition. Despite relatively high oxidation potentials, these donor molecules with CF3 EWG can be involved in charge transfer complexes or cation radical salts, as reported here for the CF3-subsituted EDT-TTF donor molecule. A neutral charge transfer complex with TCNQ, (EDT-TTF-CF3)2(TCNQ) was isolated and characterized through alternated stacks of EDT-TTF-CF3 dimers and TCNQ in the solid state. A radical cation salt of EDT-TTF-CF3 is also obtained upon electrocrystallisation in the presence of the FeCl4 (-) anion. In this salt, formulated as (EDT-TTF-CF3)(FeCl4), the (EDT-TTF-CF3)(+•) radical cations are associated two-by-two into centrosymmetric dyads with a strong pairing of the radical species in a singlet state.

Dataset Information

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies.

Publications

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies.

Similar Datasets

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