Ontology highlight
ABSTRACT:
SUBMITTER: Cabezon M
PROVIDER: S-EPMC5922401 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Cabezón Marta M Bargay Joan J Xicoy Blanca B García Olga O Borrás Josep J Borrás Josep J Tormo Mar M Marcé Sílvia S Pedro Carme C Valcárcel David D Jiménez Maria-José MJ Guàrdia Ramón R Palomo Laura L Brunet Salut S Vall-Llovera Ferran F Garcia Antoni A Feliu Evarist E Zamora Lurdes L
Oncotarget 20180410 27
Myelodysplastic syndromes (MDS) are stem cell disorders caused by various gene abnormalities. We performed targeted deep sequencing in 39 patients with high-risk MDS and secondary acute myeloid leukemia (sAML) at diagnosis and follow-up (response and/or relapse), with the aim to define their mutational status, to establish if specific mutations are biomarkers of response to 5-azacytidine (AZA) and/or may have impact on survival. Overall, 95% of patients harbored at least one mutation. <i>TP53, D ...[more]