Ontology highlight
ABSTRACT:
SUBMITTER: Chrisman IM
PROVIDER: S-EPMC5935666 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Chrisman Ian M IM Nemetchek Michelle D MD de Vera Ian Mitchelle S IMS Shang Jinsai J Heidari Zahra Z Long Yanan Y Reyes-Caballero Hermes H Galindo-Murillo Rodrigo R Cheatham Thomas E TE Blayo Anne-Laure AL Shin Youseung Y Fuhrmann Jakob J Griffin Patrick R PR Kamenecka Theodore M TM Kojetin Douglas J DJ Hughes Travis S TS
Nature communications 20180504 1
The nuclear receptor ligand-binding domain (LBD) is a highly dynamic entity. Crystal structures have defined multiple low-energy LBD structural conformations of the activation function-2 (AF-2) co-regulator-binding surface, yet it remains unclear how ligand binding influences the number and population of conformations within the AF-2 structural ensemble. Here, we present a nuclear receptor co-regulator-binding surface structural ensemble in solution, viewed through the lens of fluorine-19 (<sup> ...[more]