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Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy.


ABSTRACT: Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC?=?53%, HL?=?57%, FL?=?72%, EFW?=?71%; p?

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC5940684 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy.

Workalemahu Tsegaselassie T   Grantz Katherine L KL   Grewal Jagteshwar J   Zhang Cuilin C   Louis Germaine M Buck GMB   Tekola-Ayele Fasil F  

Scientific reports 20180508 1


Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospec  ...[more]

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