Ontology highlight
ABSTRACT:
SUBMITTER: Coutts AS
PROVIDER: S-EPMC5951837 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Coutts Amanda S AS Munro Shonagh S La Thangue Nicholas B NB
Cell death & disease 20180501 5
A prerequisite for protein synthesis is the transcription of ribosomal rRNA genes by RNA polymerase I (Pol I), which controls ribosome biogenesis. UBF (upstream binding factor) is one of the main Pol I transcription factors located in the nucleolus that activates rRNA gene transcription. E2F7 is an atypical E2F family member that acts as a transcriptional repressor of E2F target genes, and thereby contributes to cell cycle arrest. Here, we describe an unexpected role for E2F7 in regulating rRNA ...[more]