Ontology highlight
ABSTRACT:
SUBMITTER: Yang FM
PROVIDER: S-EPMC5983344 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Yang Feng-Ming FM Zuo Yong Y Zhou Wei W Xia Chuan C Hahm Bumsuk B Sullivan Mark M Cheng Jinke J Chang Hui-Ming HM Yeh Edward Th ET
The Journal of clinical investigation 20180507 6
Many Toll-like receptors (TLRs) signal through TNF receptor-associated factor 6 (TRAF6) to activate innate immune responses. Here, we show that somatic nuclear autoantigenic sperm protein (sNASP) binds to TRAF6 to prevent TRAF6 autoubiquitination in unstimulated macrophages. Following LPS stimulation, a complex consisting of sNASP, TRAF6, IRAK4, and casein kinase 2 (CK2) is formed. CK2 phosphorylates sNASP at serine 158, allowing sNASP to dissociate from TRAF6. Free TRAF6 is then autoubiquitinat ...[more]