Ontology highlight
ABSTRACT:
SUBMITTER: Weinreich DM
PROVIDER: S-EPMC5986866 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Weinreich Daniel M DM Lan Yinghong Y Jaffe Jacob J Heckendorn Robert B RB
Journal of statistical physics 20180207 1
The effect of a mutation on the organism often depends on what other mutations are already present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise epistatic effects have been recognized for over a century, and their evolutionary implications have received theoretical attention for nearly as long. However, pairwise epistatic interactions themselves can vary with genomic background. This is called higher-order epistasis, and its consequences for evolution ar ...[more]