Ontology highlight
ABSTRACT:
SUBMITTER: Rijpma A
PROVIDER: S-EPMC5987799 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Rijpma Anne A van der Graaf Marinette M Meulenbroek Olga O Olde Rikkert Marcel G M MGM Heerschap Arend A
NeuroImage. Clinical 20180228
In Alzheimer's disease (AD), defects in essential metabolic processes for energy supply and phospholipid membrane function have been implicated in the pathological process. However, post-mortem investigations are generally limited to late stage disease and prone to tissue decay artifacts. In vivo assessments of high energy phosphates, tissue pH and phospholipid metabolites are possible by phosphorus MR spectroscopy (<sup>31</sup>P-MRS), but so far only small studies, mostly focusing on single br ...[more]