Ontology highlight
ABSTRACT:
SUBMITTER: Le Y
PROVIDER: S-EPMC5988690 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Le Yi Y Gao Hong H Bleday Ronald R Zhu Zhenglun Z
Nature communications 20180605 1
Immune suppression in the tumor microenvironment (TME) is a central obstacle to effective immunotherapy. Tumor-associated macrophages (TAMs) are key components of the TME. Although TAMs have been viewed as an ideal target of intervention to steer immunity in cancer treatment, the approach has been hampered by the lack of knowledge of how TAM plasticity is controlled by cell intrinsic factors. VentX is a homeobox protein implicated in proliferation and differentiation of human hematopoietic and i ...[more]