Ontology highlight
ABSTRACT:
SUBMITTER: Ge J
PROVIDER: S-EPMC6005422 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Ge Jianfeng J Burnier Laurent L Adamopoulou Maria M Kwa Mei Qi MQ Schaks Matthias M Rottner Klemens K Brakebusch Cord C
The Journal of biological chemistry 20180426 24
Mesenchymal stem cells (MSC) are suggested to be important progenitors of myofibroblasts in fibrosis. To understand the role of Rho GTPase signaling in TGFβ-induced myofibroblast differentiation of MSC, we generated a novel MSC line and its descendants lacking functional Rho GTPases and Rho GTPase signaling components. Unexpectedly, our data revealed that Rho GTPase signaling is required for TGFβ-induced expression of α-smooth muscle actin (αSMA) but not of collagen I α1 (<i>col1a1</i>). Whereas ...[more]